Question: What Different Types Of Pigments Are Commonly Seen In Histology?

What is the most common exogenous pigment?

Examples of exogenous pigments are carbon, asbestos fibers, tattoo ink, and metals.

Copper is the most commonly visualized exogenous pigment found in liver tissue.

Accumulation found within the liver is characteristic of Wilson’s disease..

What are the three basic stains?

Basic stains, such as methylene blue, Gram safranin, or Gram crystal violet are useful for staining most bacteria.

What are the special stains in histopathology?

Special StainsHemotoxylin & Eosin (H & E) – The most widely used stain in medical diagnosis. … AFB – This is a stain used for Mycobacterium, Nocardia, endospores, and a few parasites. … Alcian Blue/PAS (also known as AB/PAS) – The primary purpose of this stain is to view both neutral and acidic mucosubstances.More items…

What does pigment mean?

noun. a dry insoluble substance, usually pulverized, which when suspended in a liquid vehicle becomes a paint, ink, etc. a coloring matter or substance. Biology. any substance whose presence in the tissues or cells of animals or plants colors them.

Why lipofuscin is called the wear and tear pigment?

Lipofuscin is sometimes called “wear-and-tear pigment”, since the amount increases over time (i.e., with advancing age) in cells like hepatocytes and neurons which are both permanent (not routinely replenished) and metabolically active. … Each of these cell types has a characteristic position.

What are pigments in histopathology?

2 Artifact pigments These are deposits of artifactually produced material caused by the interactions between certain tissue components and some chemical substances, such as the fixative formalin.

What are endogenous pigments?

Endogenous Pigments. Endogenous pigments are characterized as hematogenous and nonhematogenous. Hematogenous pigments originate from blood and nonhematogenous pigments originate from non-blood, fat or fatlike, and non-fatlike substances.

What is lipofuscin pigment?

Lipofuscin is a fluorescent pigment that accumulates with age in the lysosomal compartment of postmitotic cells in several tissues, such as neurons and heart and skeletal muscle among many others. … RPE lipofuscin can act as a photosensitizer, generating reactive oxygen species, and mediating light-induced damage.

What is ceroid pigment?

Pigmentation. Accumulation of ceroid (lipofuscin) pigment is a common age-related change in stromal cells of the rodent ovary, as in a number of other steroid secreting tissues including Leydig cells and the adrenal cortex.

What are the three types of stains?

There are three broad categories of biological stains:General or Routine Stains: Used to differentiate between the nucleus and the cytoplasm. … Special Stains: These are used to demonstrate specific elements within the tissue, such as connective tissue, muscle, carbohydrates, lipids, pigments, and nerve tissue.More items…

How is lipofuscin formed?

Numerous studies indicate that the formation of lipofuscin is due to the oxidative alteration of macromolecules by oxygen-derived free radicals generated in reactions catalyzed by redox-active iron of low molecular weight. Two principal explanations for the increase of lipofuscin with age have been suggested.

How Hemosiderin is formed?

Hemosiderin often forms after bleeding (haemorrhage). When blood leaves a ruptured blood vessel, the red blood cell dies, and the hemoglobin of the cell is released into the extracellular space.

How do you prevent lipofuscin?

Calorie restriction, vitamin E, and increased glutathione appear to reduce or halt the production of lipofuscin. The nootropic drug piracetam appears to significantly reduce accumulation of lipofuscin in the brain tissue of rats. Other possible treatments: Centrophenoxine.

How many types of stains are there?

Seven Types of Stain. We use the term “stain” to identify a colorant we apply to wood to change its color. But stains are not equal. Besides the obvious differences in color, there are at least seven categories of commercial stains that each apply and color differently.